On water N -arylation of oxetanylamines for the preparation of N -aryl-oxetanylamines; potentially useful aryl-amide isosteres

Maud Bollenbach; William Lecroq; Patrick Wagner; Thomas Fessard; Martine Schmitt; Christophe Salomé

doi:10.1039/c8cc09110b

Journal articles

On water N -arylation of oxetanylamines for the preparation of N -aryl-oxetanylamines; potentially useful aryl-amide isosteres

Maud Bollenbach William Lecroq Patrick Wagner ¹ Thomas Fessard Martine Schmitt ¹ Christophe Salomé ¹

1 LIT - Laboratoire d'Innovation Thérapeutique

Abstract : A Pd cross-coupling approach for the synthesis of N-aryl-oxetanyl-amines has been developed. This method provides new building blocks potentially useful in medicinal chemistry as amide bioisosteres. The reactions are conducted in water employing the renewable feedstock surfactant TPGS-750-M.

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Journal articles

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Chemical Sciences / Catalysis

Chemical Sciences / Organic chemistry

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Submitted on : Tuesday, October 22, 2019 - 1:07:40 PM
Last modification on : Saturday, November 2, 2019 - 1:17:30 AM

On water N -arylation of oxetanylamines for the preparation of N -aryl-oxetanylamines; potentially useful aryl-amide isosteres

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On water N -arylation of oxetanylamines for the preparation of N -aryl-oxetanylamines; potentially useful aryl-amide isosteres

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