Octogenarians with EGFR-mutated non-small cell lung cancer treated by tyrosine-kinase inhibitor a multicentric real-world study assessing tolerance and efficacy (OCTOMUT study)

Abstract : Objective. To assess efficacy and tolerance of EGFR tyrosine-kinase inhibitors (TKIs) for advanced EGFR-mutated non-small cell lung cancer (NSCLC) in octogenarians. Patients and methods. Patients aged 80 years or older with EGFR-mutated NSCLC treated by EGFR TKI between January 2011 and March 2015 whatever the line of treatment were retrospectively selected. Results. 20 centers retrospectively included 114 patients (women, 77.2%; Caucasians, 98.3%; mean age, 83.9 years). A performance status of 0–1 or 2–3 at diagnosis was reported for 71.6% and 28.4% of patients, respectively. Overall, 95.6% of patients had adenocarcinomas and histological stage at diagnosis was stage IV for 79.8% of patients. EGFR mutations were identified mainly on exon 19 (46.5%) and exon 21 (40.4%). A geriatric assessment was performed in 35.1% of patients. TKI treatment was administered to 97.3% of patients as first or second line of treatment. Overall response rate and disease control rate were 63.3% (69/109) and 78.9% (86/109), respectively. Median progression-free survival was 11.9 months (95% confidence interval [CI], 8.6–14.7) and median overall survival was 20.9 months (95% CI, 14.3–27.1). After progression, 36/95 (37.9%) patients received a new line of chemotherapy. Main toxicities were cutaneous for 66.7% of patients (grade 3–4, 10%), diarrhea for 56.0% (grade 3–4, 15%; grade 5, 2%) and others for 25.7% (grade 3–4, 41%). Conclusions. Octogenarians with EGFR-mutated NSCLC treated by EGFR TKI had clinical outcomes and toxicity profile comparable to younger patients. Geriatric assessment appeared to be underused in this population.
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Oncotarget, Impact journals, 2018, 9 (9), pp.8253-8262. 〈10.18632/oncotarget.23836〉
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01744405
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Soumis le : mardi 9 octobre 2018 - 14:13:37
Dernière modification le : mercredi 10 octobre 2018 - 01:25:38

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Romain Corre, Radj Gervais, Florian Guisier, Louis Tassy, Florent Vinas, et al.. Octogenarians with EGFR-mutated non-small cell lung cancer treated by tyrosine-kinase inhibitor a multicentric real-world study assessing tolerance and efficacy (OCTOMUT study). Oncotarget, Impact journals, 2018, 9 (9), pp.8253-8262. 〈10.18632/oncotarget.23836〉. 〈hal-01744405〉

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