L. Abramovsky, R. Griffith, G. Mcartney, and H. Miller, The location of innovative activity in Europe, IFS Working Papers W08/10. Institute for Fiscal Studies, 2008.

B. B. Allred and W. G. Park, Patent rights and innovative activity: evidence from national and firm-level data, Journal of International Business Studies, vol.50, issue.6, pp.878-900, 2007.
DOI : 10.1287/mnsc.1040.0208

P. Almeida, Knowledge sourcing by foreign multinationals: Patent citation analysis in the U.S. semiconductor industry, Strategic Management Journal, vol.34, issue.2, pp.155-165, 1996.
DOI : 10.2307/41166695

B. Ambos, Foreign direct investment in industrial research and development: A study of German MNCs, Research Policy, vol.34, issue.4, pp.395-410, 2005.
DOI : 10.1016/j.respol.2005.01.016

C. A. Bartlett and S. Ghoshal, Managing Across Borders: The Transnational Solution, 1989.
DOI : 10.1007/978-1-137-28787-8_25

M. Baudry, B. Dumont, and A. Dierx, Measuring Inventive Performance of the OECD Countries Using Triadic Patent Families: Reinventing the Lisbon Challenge, Competitiveness and Growth in Europe, chapter 9, 2006.
DOI : 10.4337/9781781007464.00018

URL : https://hal.archives-ouvertes.fr/halshs-00010397

K. Bjorvatn and C. Eckel, Technology Sourcing and Strategic Foreign Direct Investment, Review of International Economics, vol.87, issue.4, pp.600-614, 2006.
DOI : 10.1162/00346530152480135

URL : https://brage.bibsys.no/xmlui/bitstream/11250/162800/1/dp2001-28.pdf

K. Blind and R. Frietsch, Sector-based multidimensional forecasting model (seform), report to the European patent office within the research programme: improvement of methods for forecasting patentfilings, 2003.

D. Bosworth, The Management of Intellectual Property: introduction The Management of Intellectual, 2006.
DOI : 10.4337/9781847201553

G. Bottazzi, G. Dosi, M. Lippi, F. Pammolli, and M. Riccaboni, Innovation and corporate growth in the evolution of the drug industry, International Journal of Industrial Organization, vol.19, issue.7, pp.1161-1187, 2001.
DOI : 10.1016/S0167-7187(01)00068-6

L. Branstetter, Is foreign direct investment a channel of knowledge spillovers? Evidence from Japan's FDI in the United States, Journal of International Economics, vol.68, issue.2, pp.325-344, 2006.
DOI : 10.1016/j.jinteco.2005.06.006

J. Cantwell, The globalisation of technology: what remains of the product cycle model?, Cambridge Journal of Economics, vol.19, issue.1, pp.155-174, 1995.

J. Cantwell and S. Iammarino, Multinational Corporations and the Location of Technological Innovation in the UK Regions, Regional Studies, vol.28, issue.2, pp.317-332, 2000.
DOI : 10.1016/S0048-7333(98)00113-9

H. P. Chan, THE DETERMINANTS OF INTERNATIONAL PATENTING FOR NINE AGRICULTURAL BIOTECHNOLOGY FIRMS*, The Journal of Industrial Economics, vol.13, issue.(3, pp.247-278, 2010.
DOI : 10.1111/j.1467-6451.2010.00420.x

S. Chaudhuri, P. Goldberg, G. , and P. , Estimating the Effects of Global Patent Protection in Pharmaceuticals: A Case Study of Quinolones in India, American Economic Review, vol.96, issue.5, pp.1477-1514, 2006.
DOI : 10.1257/aer.96.5.1477

Y. C. Chen, Why Do Multinational Corporations Locate Their Advanced R&D Centres in Beijing?, The Journal of Development Studies, vol.3, issue.5, pp.622-644, 2008.
DOI : 10.1111/j.1944-8287.2003.tb00205.x

I. M. Cockburn, J. O. Lanjouw, and M. Schankerman, Patents and the Global Diffusion of New Drugs, American Economic Review, vol.106, issue.1, pp.136-64, 2016.
DOI : 10.1257/aer.20141482

W. M. Cohen, R. R. Nelson, W. , and J. P. , Protecting Their Intellectual Assets: Appropriability Conditions and Why U.S. Manufacturing Firms Patent (Or Not), 2000.
DOI : 10.3386/w7552

G. De-rassenfosse, H. Dernis, D. Guellec, L. Picci, and B. Van-pottelsberghe-de-la-potterie, The worldwide count of priority patents: A new indicator of inventive activity, Research Policy, vol.42, issue.3, pp.720-737, 2013.
DOI : 10.1016/j.respol.2012.11.002

G. De-rassenfosse and B. Van-pottelsberghe-de-la-potterie, A policy insight into the R&D???patent relationship, Research Policy, vol.38, issue.5, pp.779-792, 2009.
DOI : 10.1016/j.respol.2008.12.013

H. Dernis and M. Khan, Triadic patent families methodology, OECD STI working paper, 2004.
DOI : 10.1787/443844125004

Y. L. Doz, K. Wilson, S. Veldhoen, T. Goldbrunner, and G. Altman, Innovation: is global the way forward? A joint study by Booz, 2006.

J. H. Dunning, The economic theory of the firm as the basis for a 'core' theory of international production, Current issues in international business, pp.60-68, 1997.

I. W. Fisher and F. Oberholzer-gee, Strategic Management of Intellectual Property: An Integrated Approach, California Management Review, vol.55, issue.4, pp.157-183, 2013.
DOI : 10.1525/cmr.2013.55.4.157

R. Florida, The globalization of R&D: Results of a survey of foreign-affiliated R&D laboratories in the USA, Research Policy, vol.26, issue.1, pp.85-103, 1997.
DOI : 10.1016/S0048-7333(97)00004-8

T. S. Frost, The geographic sources of foreign subsidiaries' innovations, Strategic Management Journal, vol.18, issue.2, pp.101-123, 2001.
DOI : 10.1002/(SICI)1097-0266(199706)18:6<439::AID-SMJ884>3.0.CO;2-Y

P. Gammeltoft, Internationalisation of R&D: trends, drivers and managerial challenges, International Journal of Technology and Globalisation, vol.2, issue.1/2, pp.1-2, 2006.
DOI : 10.1504/IJTG.2006.009133

S. Grimes and M. Miozzo, Big Pharma's Internationalization of R&D to China, European Planning Studies, vol.91, issue.27, pp.1873-1894, 2015.
DOI : 10.1080/00343401003604663

H. Grupp and U. Schmoch, Patent statistics in the age of globalisation: new legal procedures, new analytical methods, new economic interpretation, Research Policy, vol.28, issue.4, pp.377-396, 1999.
DOI : 10.1016/S0048-7333(98)00125-5

F. Malerba and L. Orsenigo, The evolution of the pharmaceutical industry, Business History, vol.6, issue.4, pp.664-687, 2015.
DOI : 10.1093/icc/3.2.451

URL : https://hal.archives-ouvertes.fr/halshs-01074520

K. Maskus, Intellectual Property Rights in the Global Economy, 2000.

M. Mazzucato, D. , and G. , Knowledge accumulation and industry evolution: The case of Pharma-Biotech, 2010.
DOI : 10.1017/CBO9780511493232

P. Moncada-paternò-castello, M. Vivarelli, and P. Voigt, Drivers and impacts in the globalization of corporate R&D: an introduction based on the European experience, Industrial and Corporate Change, vol.31, issue.1, pp.585-603, 2011.
DOI : 10.1016/S0048-7333(01)00125-1

R. Narula and J. And-guimón, The investment development path in a globalised world: Implications for eastern Europe, Eastern Journal of European Studies, vol.1, issue.2, pp.5-19, 2010.

R. Narula and A. Zanfei, Globalisation of innovation: the role of multinational enterprises The Oxford Handbook of Innovation, pp.318-345, 2005.

P. Neuhausler and R. Frietsch, Patent families as macro level patent value indicators: applying weights to account for market differences, Scientometrics, vol.48, issue.3, pp.27-49, 2013.
DOI : 10.2307/1912934

H. Odagiri, Y. , and H. , The determinants of overseas R&D by Japanese firms: an empirical study at the industry and company levels, Research Policy, vol.25, issue.7, pp.1059-1079, 1996.
DOI : 10.1016/S0048-7333(96)00892-X

W. G. Park, International patent protection: 1960???2005, Research Policy, vol.37, issue.4, pp.761-766, 1960.
DOI : 10.1016/j.respol.2008.01.006

P. Patel and K. Pavitt, Large Firms in the Production of the World's Technology: An Important Case of ???Non-Globalisation???, Journal of International Business Studies, vol.22, issue.1, pp.1-21, 1991.
DOI : 10.1057/palgrave.jibs.8490289

P. Patel and M. Vega, Patterns of internationalisation of corporate technology: location vs. home country advantages, Research Policy, vol.28, issue.2-3, pp.2-3, 1999.
DOI : 10.1016/S0048-7333(98)00117-6

L. Piscitello, Strategy, location, and the conceptual metamorphosis of the MNC, Global Strategy, vol.1, pp.1-2, 2011.

I. Rafols, M. M. Hopkins, J. Hoekman, J. Siepel, J. O-'hare et al., Big Pharma, Little Science? A Bibliometric Perspective on Big Pharma???s R&D Decline, SSRN Electronic Journal, vol.81, pp.22-38, 2014.
DOI : 10.2139/ssrn.2012878

URL : http://eprints.rclis.org/24128/1/Rafols_2012_preprint.pdf

E. B. Roberts, Benchmarking Global Strategic Management of Technology, Research-Technology Management, vol.44, issue.2, pp.71-88, 2001.
DOI : 10.1080/08956308.2001.11671416

N. Roijakkers and J. Hagedoorn, Inter-firm R&D partnering in pharmaceutical biotechnology since 1975: Trends, patterns, and networks, Research Policy, vol.35, issue.3, pp.431-446, 2006.
DOI : 10.1016/j.respol.2006.01.006

R. C. Ronstadt, International R&D: The Establishment and Evolution of Research and Development Abroad by Seven U.S. Multinationals, Journal of International Business Studies, vol.9, issue.1, pp.7-24, 1978.
DOI : 10.1057/palgrave.jibs.8490647

A. M. Rugman, Inside the multinationals: The economics of internal markets, 1981.

W. Ryuhei and I. Banri, The Effects of Stronger Intellectual Property Rights on Technology Transfer: Evidence from Japanese Firm-level Data, KIER Working Papers, vol.632, 2007.

F. Sachwald, Location choices within global innovation networks: the case of Europe, The Journal of Technology Transfer, vol.41, issue.1, pp.364-378, 2008.
DOI : 10.2307/41166042

K. Saggi, Trade, foreign direct investment, and international technology transfer: A survey, The World Bank Research Observer, pp.191-235, 2002.
DOI : 10.1596/1813-9450-2349

URL : http://econ.worldbank.org/files/1103_wps2349.pdf

C. Sternitzke, Defining triadic patent families as a measure of technological strength, Scientometrics, vol.25, issue.1, pp.91-109, 2009.
DOI : 10.1007/978-3-322-90020-3

M. Von-zedtwitz and O. Gassmann, Market versus technology drive in R&D internationalization: four different patterns of managing research and development, Research Policy, vol.31, issue.4, pp.569-588, 2002.
DOI : 10.1016/S0048-7333(01)00125-1

. Lilly and . Usa, Some of them merged later17)* 13.40(3.71)*** firm_intercontinent alpatent_pct2 -16, 05)*** 1.8(2.00)* 12.60(4.40)*** 2.86(1.61) 15.70(4.28)*** 2.02, 2009.