Fast and complete removal of the 5-fluorouracil drug from water by electro-Fenton oxidation

Abstract : Cytostatic drugs are one of the most troublesome classes of emerging pollutants in water owing to their toxicity and potential effects on DNA. This study addresses, for the first time, the optimization of the electro-Fenton process for the removal of cytotoxic drug 5-fluorouracil from water using a BDD anode and a carbon felt cathode. As demonstrated from chromatographic and TOC analyses, the optimal catalyst concentration was 0.2 mM Fe 2+ , allowing the quickest drug degradation and almost complete mineralization at 300 and 1500 mA, respectively. The absolute rate constant for oxidation of 5-fluorouracil by hydroxyl radicals was found to be (1.52 ± 0.01) × 10 9 M-1 s-1. During the electrolyses, linear carboxylic acids (oxalic and acetic) were formed and destroyed, whereas the final solution at 360 min mainly contained some inorganic ions (NH 4 + , NO 3 − and F −) and < 10% TOC. Hence, electro-Fenton process constitutes an interesting alternative for the degradation of (bio)refractory drugs.
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O. Ganzenko, Nihal Oturan, I. Sirés, David Huguenot, Eric D. van Hullebusch, et al.. Fast and complete removal of the 5-fluorouracil drug from water by electro-Fenton oxidation. Environmental Chemistry Letters, Springer Verlag, 2018, 16 (1), pp.281-286. ⟨10.1007/s10311-017-0659-6⟩. ⟨hal-01635073⟩

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