Abstract : Bio-artificial tissues are being developed as replacements for damaged biologic tissues and their mechanical properties are critical for load-bearing applications. Reconstituted dense three-dimensional (3D) fibrillar collagen matrices are promising materials for tissue engineering, at the light of their interaction with fibroblasts.1,2 The mechanical properties of these fibrillar collagen matrices are now being characterized under unconfined compression loading for various strain rates and collagen concentrations. The data were compared to those obtained in the same conditions with a biological tissue, the rat dermis. The results show a very sensitive behavior to both the displacement rate, typical of biological soft tissues, and the collagen concentration varying between 5 and 40 mg/ml. The link between the mechanical properties and the microscopic structure of the collagen scaffolds show an increasing viscoelastic modulus with respect to the fibril density. It is found that the matrices at 5 mg/ml and the dorsal rat skin (DRS) exhibit similar stress–strain response when submitted to the same external unconfined compression load. Such results highlight the interest of these matrices as potential tissue substitutes.
