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Article Dans Une Revue Medical Hypotheses Année : 2012

Possible role of calcium permselectivity in bone adaptation

Résumé

According to the core activity of calcium in the bone cellular expression, a new hypothesis linking calcium transport with the mechanical loading is proposed to explain the mechano-adaptation of bone tissue. Due to the piezoelectric coupling, the tensile and compressive areas of bone produce different electrical environments for the osteocytic cells that are embedded in the lacuno-canalicular porosity. This electrical asymmetry engenders a calcium enrichment-exclusion effect that strongly changes the calcium concentration in the lacuno-canalicular fluid and thus modifies the remodelling process. A bibliographic body of evidence supporting this idea is given and its experimental validation is suggested. (C) 2011 Elsevier Ltd. All rights reserved.

Dates et versions

hal-00692642 , version 1 (01-05-2012)

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T. Lemaire, S. Naili. Possible role of calcium permselectivity in bone adaptation. Medical Hypotheses, 2012, 78 (3), pp.367--369. ⟨10.1016/j.mehy.2011.12.005⟩. ⟨hal-00692642⟩
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