Time-varying delays in electrophysiological wave propagation along cardiac tissue and minimax control problems associated with uncertain bidomain type models

Aziz Belmiloudi (1)

1 IRMAR - Institut de Recherche Mathématique de Rennes

Motivated by topics and issues critical to human health, the problem studied in this work derives from the modeling and stabilizing control of electrical cardiac activity in order to maximize the efficiency and safety of treatment for cardiac disease. In this paper we consider nonlinear minimax control problems constrained by an uncertain modified bidomain model of cardiac tissue electrophysiology system, in order to take into account the influence of noises in data and time-delays in signal transmission. The state system is a degenerate nonlinear coupled system of reaction-diffusion equations in the shape of a set of delay differential equations coupled with a set of delay partial differential equations with multiple time-varying delays. The concept of our minimax control approach consists in setting the problem in the worst-case disturbances which leads to the game theory in which the controls and disturbances play antagonistic roles. The proposed strategy consists in controlling these instabilities by acting on certain data to maintain the system in a desired state. First, the mathematical model is introduced and its well-posedness is studied. Second, the minimax control problem is formulated. Afterwards the Fréchet differentiability of nonlinear solution map from the couple control-disturbance input to the solution of state system is assessed as well as stability of the derived sensitive system. The existence of an optimal solution is proved and first-order necessary optimality conditions are established by using sensitivity and adjoint calculus.

Mots clés: Mathematical modeling for medicine; bidomain type model; parabolic-elliptic coupling; ionic model; cardiac electrophysiology; minimax control; multiple time-varying delays; electrotherapy; reaction-diffusion system; fluctuation; adjoint model; sensitive model; necessary conditions of optimality

Domaines: Analyse numérique [math.NA]

Aziz Belmiloudi. Time-varying delays in electrophysiological wave propagation along cardiac tissue and minimax control problems associated with uncertain bidomain type models. AIMS Mathematics, 2019, 4 (3), pp.928-983. ⟨10.3934/math.2019.3.928⟩. ⟨hal-02292593⟩