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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Amarnath Rambhatla, Rupin Shah, Imad Ziouziou, Priyank Kothari, Gianmaria Salvio, et al.. Global Practice Patterns and Variations in the Medical and Surgical Management of Non-Obstructive Azoospermia: Results of a World-Wide Survey, Guidelines and Expert Recommendations. The World Journal of Men's Health, 2024, 42, ⟨10.5534/wjmh.230339⟩. ⟨hal-04569819⟩
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Nicolas Jovanovic, Vicente Mustieles, Marc Althuser, Sarah Lyon-Caen, Nadia Alfaidy, et al.. Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy. Human Reproduction Open, 2024, 2024, ⟨10.1093/hropen/hoae018⟩. ⟨hal-04569675⟩
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Géraldine Porcu-Buisson, Chloé Maignien, Nelly Swierkowski-Blanchard, Catherine Rongières, Noémie Ranisavljevic, et al.. Prospective multicenter observational real-world study to assess the use, efficacy and safety profile of follitropin delta during IVF/ICSI procedures (DELTA Study). European Journal of Obstetrics & Gynecology and Reproductive Biology, 2024, 293, pp.21-26. ⟨10.1016/j.ejogrb.2023.12.011⟩. ⟨inserm-04391221⟩
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Rossella Cannarella, Rupin Shah, Ramadan Saleh, Florence Boitrelle, Taha Abo-Almagd Abdel-Meguid Hamoda, et al.. Effects of Varicocele Repair on Sperm DNA Fragmentation and Seminal Malondialdehyde Levels in Infertile Men with Clinical Varicocele: A Systematic Review and Meta-Analysis. The World Journal of Men's Health, 2024, 42, ⟨10.5534/wjmh.230235⟩. ⟨hal-04402641⟩
References
2 231
Open Access
33 %
Keywords
Placenta
Chorion
Mouse
Development
Mammary gland
DNA methylation
Pluripotency
Sex determination
Implantation
Foetus
Pregnancy
Rabbit
Mare
Inflammation
Epigénétique
Développement
Dna methylation
Conceptus
Animal modèle
Embryo transfer
Ovary
Cheval
Foxl2
Cattle
Nutrition
Phénotype
IMAGE
Spermatozoa
Nuclear transfer
IMMUNOLOGIE
Uterus
Spermatogenesis
Horse
IMAGERIE
Gestation
Jument
Épigénétique
Male
Sheep
Obésité
Obesity
Embryon
Meiosis
Bovin
Endometrium
Female
Sexual dimorphism
Methylation
Somatic cell nuclear transfer
Infertility
Blastocyst
Transcriptome
Fertility
BIOLOGIE DU DEVELOPPEMENT
Animal models
Métabolisme
Male infertility
Dohad
Oxidative stress
GENETIQUE
Equine
Epigenetics
EMBRYO
These
Fertilité
Poulain
Trophoblast
Progesterone
PLACENTA
GENOMIQUE
Programming
NUCLEAR TRANSFER
Programmation foetale
Epigenetic
Reproduction
Diesel
Animal model
Embryo
Growth
Humans
Souris
Alimentation
Développement embryonnaire
Lapin
BIOTECHNOLOGIE
Gene expression
Oocyte
Endomètre
Mice
Dairy cow
DOHaD
Sperm
Goat
Méthylation
Environment
Ruminant
Adult
Fetal programming
Ovaire
Bovine